Director: Jenny Munson, Ph.D.
Publications
Patient-designed models of the invasive edge of glioblastoma
RC Cornelison, JX Yuan, KM Tate, A Petrosky†, GF Beeghly, M Bloomfield, SC Schwager†, AL Berr†, D Cimini, FF Bafakih, JW Mandell, BW Purow, BJ Horton, JM Munson*. A patient-designed tissue-engineered model of the infiltrative glioblastoma microenvironment, NPJ Precision Oncology.6(54) 2022. Available: https://rdcu.be/cXtxU
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Cell migration in response to flow and endothelial cell interactions
L. M. Roberts, M. J. Perez, K. N. Balogh, G. Mingledorff, J. V. Cross, and J. M. Munson, “Myeloid Derived Suppressor Cells Migrate in Response to Flow and Lymphatic Endothelial Cell Interaction in the Breast Tumor Microenvironment,” Cancers, vol. 14, no. 12, Art. no. 12, Jan. 2022, doi: 10.3390/cancers14123008.
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Lymphangiogenesis to be prevented with Anti-VEGFR3 therapy
A. R. Harris et al., “Platinum Chemotherapy Induces Lymphangiogenesis in Cancerous and Healthy Tissues That Can be Prevented With Adjuvant Anti-VEGFR3 Therapy,” Frontiers in Oncology, vol. 12, 2022, Accessed: Jun. 27, 2022. [Online]. Available: https://www.frontiersin.org/article/10.3389/fonc.2022.801764
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Repeatability of tumor perfusion kinetics
R. T. Woodall et al., “Repeatability of tumor perfusion kinetics from dynamic contrast-enhanced MRI in glioblastoma,” Neuro-Oncology Advances, vol. 3, no. 1, p. vdab174, Jan. 2021, doi: 10.1093/noajnl/vdab174.
Gradient formation in interstitial fluid flow environments
C. A. Stine and J. M. Munson, “Autologous Gradient Formation under Differential Interstitial Fluid Flow Environments,” Biophysica, vol. 2, no. 1, Art. no. 1, Mar. 2022, doi: 10.3390/biophysica2010003.
Tissue engineering models of breast cancer
J. A. McGuire et al., “Tear propagation in vaginal tissue under inflation,” Acta Biomaterialia, vol. 127, pp. 193–G. F. Beeghly, C. Thomas, J. X. Yuan, A. R. Harris, and J. M. Munson, “Designing Patient-Driven, Tissue-Engineered Models of Primary and Metastatic Breast Cancer,” Bioengineering, vol. 9, no. 2, Art. no. 2, Feb. 2022, doi: 10.3390/bioengineering9020044.
Engineering advances for women’s health
R. De Vita and J. Munson, “Special Issue on the Advances in Engineering for Women’s Health,” Ann Biomed Eng, vol. 49, no. 8, pp. 1785–1787, Aug. 2021, doi: 10.1007/s10439-021-02837-5.
Tear propagation in vaginal tissue
J. A. McGuire et al., “Tear propagation in vaginal tissue under inflation,” Acta Biomaterialia, vol. 127, pp. 193–204, Jun. 2021, doi: 10.1016/j.actbio.2021.03.065.
Ultrasound promotes nanoparticle dispersion and transfection
Curley T., Colleen et al. Augmentation of brain tumor interstitial flow via focused ultrasound promotes brain-penetrating nanoparticle dispersion and transfection. Science Advances, vol. 6, no. 18, p. eaay1344, May 2020, doi: 10.1126/sciadv.aay1344.
Measuring interstitial fluid flow in glioblastoma patients
Atay, Chatterjee, et al. Utilizing Dynamic Contrast-Enhanced Magnetic Resonance Imaging (DCE-MRI) to Analyze Interstitial Fluid Flow and Transport in Glioblastoma and the Surrounding Parenchyma in Human Patients. Pharmaceutics. 13 (2): 212 (2021). doi: 10.3390/pharmaceutics13020212
Focused Ultrasound-mediated blood brain barrier opening increases interstitial fluid flow
Curley, et al. Augmentation of brain tumor interstitial flow via focused ultrasound promotes brain-penetrating nanoparticle dispersion and transfection. Science Advances.6(18): eaay1344 (2020). DOI: 10.1126/sciadv.aay1344
Review: Engineering the tumor microenvironment
LM Roberts, JM Munson, Modulating microenvironments for treating glioblastoma. Current tissue microenvironment reports. 1, 99-111 (2020)
Review: Studying fluid flow in the brain
KC Chatterjee, CA Carman-Esparza, JM Munson, Methods to measure, model, and manipulate fluid flow in the brain. Neuroscience Methods. 333: 108541. (2020) https://doi.org/10.1016/j.jneumeth.2019.108541
Review: Linking CED to interstitial flow
CA Stine, JM Munson, Convection enhanced delivery: role of increased interstitial fluid flow. Frontiers: Oncology. 9: 966 (2019).
Review: Systems for testing drugs for nervous disorders
1. KM Tate, JM Munson, Assessing drug response in engineered neural microenvironments. Brain Research Bulletin. 150: 21-34 (2019). DOI: 10.1016/j.brainresbull.2019.04.027
Increased fluid flow in vivo leads to increased glioma invasion
RC Cornelison, KM Kingsmore, CR Brennan, JM Munson, Functional aspects of meningeal lymphatics in ageing and Alzheimer’s disease. Nature. (2018). DOI: 10.1038/s41586-018-0368-8.
Increasing meningeal lymphangiogenesis to boost memory
S Da Mesquita, A Louveau, A Vaccari, I Smirnov, RC Cornelison, KM Kingsmore, C Contarino, S Onengut-Gumuscu, E Farber, D Raper, KE Viar, W Baker, N Dabhi, G Oliver, S Rich, JM Munson, CC Overall, ST Acton, J Kipnis, Functional aspects of meningeal lymphatics in ageing and Alzheimer’s disease. Nature. (2018). DOI: 10.1038/s41586-018-0368-8.
Mapping interstitial flow in glioblastoma with MRI
Kathryn M. Kingsmore, Andrea Vaccari, Daniel Abler, Sophia X. Cui, Frederick H. Epstein, Russell C. Rockne, Scott T. Acton, and Jennifer M. Munson, MRI analysis to map interstitial flow in the brain tumor microenvironment. (2018) APL Bioengineering 18(1), 718. DOI: 10.1063/1.5023503
Common chemotherapy promotes microenvironmental changes
Alexandra R Harris, Matthew J Perez, Jennifer M. Munson , Docetaxel facilitates lymphatic-tumor crosstalk to promote lymphangiogenesis and cancer progression. (2018) BMC Cancer 18(1), 718. DOI: 10.1186/s12885-018-4619-8
How can we use in vitro models to inform biomaterial use in glioma?
R Chase Cornelison, Jennifer M. Munson, Perspective on Translating Biomaterials Into Glioma Therapy: Lessons From in Vitro Models. (2018) Frontiers Materials 5, 27. DOI: 10.3389/fmats.2018.00027
Methods for tissue engineering cancer in vitro
Alexandra R Harris, Jessica X. Yuan, Jennifer M. Munson , Assessing multiparametric drug response in tissue engineered tumor microenvironment models, Methods (2017) 134-135: 20-31. DOI: 10.1016/j.ymeth.2017.12.010
Breast cancer chemotherapy response varies at the border
Daniel K. Logsdon, Garrett F. Beeghly, Jennifer M. Munson, Chemoprotection Across the Tumor Border: Cancer Cell Response to Doxorubicin Depends on Stromal Fibroblast Ratios and Interstitial Therapeutic Transport. Cellular and Molecular Bioengineering (2017) 10(5): 463-481. DOI: 10.1007/s12195-017-0498-3
Quantitative analysis of the glioma microenvironment
Jessica X. Yuan, Jennifer M. Munson, Quantitative Immunohistochemistry of the Cellular Microenvironment in Patient Glioblastoma Resections. Journal of Visualized Experiments (2017). DOI: 10.3791/56025
The cellular microenvironment of GBM can predict survival
Jessica X. Yuan BS, Fahad F. Bafakih MD, James W. Mandell MD, PhD, Bethany J. Horton PhD, Jennifer M. Munson PhD, Quantitative Analysis of the Cellular Microenvironment of Glioblastoma to Develop Predictive Statistical Models of Overall Survival. Journal of Neuropathology and Experimental Neurology. (2016) 75(12): 1110-1123. DOI: 10.1093/jnen/nlw090
Multiple mechanisms underlie interstitial flow-stimulated invasion
KM Kingsmore, DK Logsdon, DJ Floyd, BW Purow, JM Munson, Interstitial flow differentially increases patient-derived glioblastoma stem cell invasion via CXCR4, CXCL12, and CD44-mediated mechanisms. Integrative Biology (2016) 8: 1246-1260 . DOI: 10.1039/C6IB00167J
Review: Macrophages' role in angiogenesis and lymphangiogenesis
BA Corliss, MS Azimi, JM Munson, SM Peirce, WL Murfee, Macrophages: an inflammatory link between angiogenesis and lymphangiogenesis. Microcirculation (2016) 23(2): 95-121. DOI: 10.1039/C6IB00167J
The role of interstitial flow in cancer progression
JM Munson, AC Shieh, Interstitial fluid flow in cancer: implications for disease progression and treatment. Cancer Management and Research 6: 317-328 (2014). DOI: 10.2147/CMAR.S65444
Pre-2014
New therapeutics against glioma invasion
JM Munson, MY Bonner, L Fried, JL Arbiser, RV Bellamkonda, Identifying new small molecule anti-invasive compounds for glioma treatment. Cell Cycle 12 (14):1-10 (2013).
Interstitial flow enhances glioma invasion
JM Munson, RV Bellamkonda & MA Swartz, Interstitial flow increases glioma invasion via CXCR4-dependent autologous chemotaxis in a 3D microenvironment. Cancer Research 73(5): 1536-1546 (2013)
Using nanoparticles for intraoperative glioma ID
BR Roller, JM Munson, PA Santangelo, B Brahma, RV Bellamkonda, Evans blue nanocarriers visually demarcate margins of invasive gliomas, Drug delivery and Translational Research (2013).
New nanoparticle therapy stops glioma invasion
JM Munson, L Fried, SA Rowson, MY Bonner, L Karumbaiah, B Diaz, SA Courtneidge, UG Knaus, DJ Brat, JL Arbiser, RV Bellamkonda, Anti-invasive adjuvant therapy with Imipramine Blue enhances chemotherapeutic efficacy against glioma. Science Translational Medicine 4, 127ra36 (2012).